Welcome To A New Paradigm In Bioenergetics

We are dedicated to developing life-changing medicines with a broad pipeline of first-in-class treatments addressing novel targets within the mitochondria, the primary organelles responsible for producing and regulating cellular energy. By harnessing cellular energetics, we are ushering in a new treatment paradigm for a rare and common conditions.

A Vast Opportunity For Therapeutic Innovation

We are harnessing cellular energetics to open up new therapeutic avenues for the treatment of a wide range of disease. Pretzel is building a deep, first-in-class pipeline of novel medicines designed to impede disease progression and severity across high unmet need indications spanning neurological, muscular atrophies, metabolic and rare disease.